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Also for NLRP3 (NM_001127462)
|Synthetic peptide corresponding to a region within amino acids 974 and 1036 of NLRP3 (Uniprot ID#Q96P20)|
|Human (Predicted: Mouse, Rat, Pig, Rhesus Monkey, Bovine)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (85%), Rat (92%), Pig (92%), Rhesus Monkey (92%), Bovine (92%)
|Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 5|
|AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1|
Entrez Gene 114548 Human
Entrez Gene 216799 Mouse
Entrez Gene 287362 Rat
Entrez Gene 701278 Monkey
|This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq]|
|Druggable Genome NOD-like receptor signaling pathway|
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Sample(30 ug of whole cell lysate). A:Raji. 7.5% SDS PAGE. TA309046 diluted at 1:1500