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Also for LIMK2 (NM_001031801)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 294 and 665 of LIM kinase 2|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens LIM domain kinase 2 (LIMK2), transcript variant 1|
|There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
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Sample (30ug whole cell lysate) A:293T (anti-LIMK2 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded CA922 xenograft , using LIM kinase 2(anti-LIMK2 antibody) antibody at 1:500 dilution.