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Home Antibody All anti-HLA-DRB1 antibodies

Anti-HLA-DRB1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308896
  • Rabbit polyclonal antibody to HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)
100ul 325 3-7 Days
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WB(1)
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Also for HLA-DRB1 (NM_002124)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 56 and 260 of Human HLA-DRB1
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.43mg/ml
Guaranteed Application *WB Suggested DilutionsWB:1:500-1:3000;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 1
Alternative NameDRB1; DRw10; HLA-DR1B; HLA-DRB; SS1
Database LinkNP_002115
FunctionHLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]
Related Pathway
Hematopoietic cell lineage

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A: H1299 (anti-HLA-DRB1 antibody diluted at 1:1000)

 

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