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Also for NR3C1 (NM_000176)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 235 of Human NR3C1|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1), transcript variant 1|
|GCCR; GCR; GR; GRL|
|The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq]|
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Sample (30 ug of whole cell lysate) A: A431 (anti-NR3C1 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded OVCA xenograft, using Glucocorticoid Receptor beta(anti-NR3C1 antibody) antibody at 1:100 dilution.