The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]
Related Pathway
Hematopoietic cell lineage
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Immunofluorescence analysis of paraformaldehyde-fixed human pancreatic cancer cell line, using CD44(anti-CD44 antibody) antibody at 1:50 dilution. Blue: DAPI.
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