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Home Antibody All anti-GAD2 antibodies

Anti-GAD2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308785
  • Rabbit Polyclonal antibody to GAD65 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC427399) , 20ug Explanation
100ul 325 3-7 Days
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WB(2)
IHC(1)
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Also for GAD2 (NM_001134366)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region within amino acids 465 and 558 of GAD65 (Uniprot ID#Q05329)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Dog, Pig, Rhesus Monkey) Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:5000-1:20000
Predicted MW Explanation 65kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Dog (92%), Pig (85%), Rhesus Monkey (100%)

Reference Data

Target NameHomo sapiens glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (GAD2), transcript variant 2
Alternative NameGAD65
Database LinkNP_001127838
Entrez Gene 2572 Human
Entrez Gene 14417 Mouse
Entrez Gene 613029 Monkey
Entrez Gene 487107 Dog
FunctionThis gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq]
Related PathwayDruggable Genome Alanine, aspartate and glutamate metabolismbeta-Alanine metabolismTaurine and hypotaurine metabolismButanoate metabolismMetabolic pathwaysType I diabetes mellitusMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (20 ug of whole cell lysate). A: mouse brain. 7.5% SDS PAGE. TA308785 diluted at 1:10000.
WB Image
Sample (10 ug of whole cell lysate). A: rat brain. 7.5% SDS PAGE. TA308785 diluted at 1:10000.
IHC Image
GAD65 antibody [C2C3], C-term detects GAD2 protein at cytosol on RT2 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded RT2 xenograft. GAD65 antibody [C2C3], C-term (TA308785) dilution: 1:500.

 

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