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Anti-VAV1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA308739 Rabbit polyclonal antibody to VAV1 (vav 1 guanine nucleotide exchange factor) 100ul $325 3-7 Days
LC417322 VAV1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 83 and 568 of VAV1 (Uniprot ID#P15498)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Bovine) Concentration0.33mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 98kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (92%), Rat (92%), Bovine (96%)

Reference Data

Target NameHomo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 1
Alternative NameVAV
Database LinkNP_005419
Entrez Gene 7409 Human
Entrez Gene 22324 Mouse
Entrez Gene 25156 Rat
FunctionThe protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]
Related PathwayTranscription FactorsDruggable Genome Chemokine signaling pathwayFocal adhesionNatural killer cell mediated cytotoxicityT cell receptor signaling pathwayB cell receptor signaling pathwayFc epsilon RI signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample(30 ug of whole cell lysate). A:MOLT4. B:Raji . 7.5% SDS PAGE. TA308739 diluted at 1:500
VAV1 antibody detects VAV1 protein by Western blot analysis. A. 30 ug BCL-1 whole cell lysate/extract. 7.5 % SDS-PAGE. VAV1 antibody (TA308739) dilution: 1:1000
Immunohistochemical analysis of paraffin-embedded serous OVCA, using VAV1(TA308739) antibody at 1:100 dilution.


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