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Home Antibody All anti-TYK2 antibodies

Anti-TYK2 Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA308735 Rabbit polyclonal antibody to TYK2 (tyrosine kinase 2) 100ul $325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 680 and 1187 of TYK2 (Uniprot ID#P29597)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Pig, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IF Suggested DilutionsICC/IF:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 134kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (88%), Pig (88%), Bovine (87%)

Reference Data

Target NameHomo sapiens tyrosine kinase 2 (TYK2)
Alternative NameIMD35; JTK1
Database LinkNP_003322
Entrez Gene 7297 Human
Entrez Gene 54721 Mouse
FunctionThis gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq]
Related PathwayProtein KinaseDruggable Genome Jak-STAT signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Sample(30 ug whole cell lysate). A:H1299. B:HeLa S3. 5% SDS PAGE. TA308735 diluted at 1:1000
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Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TYK2(TA308735) antibody at 1:200 dilution.
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