Home Antibody All anti-DHH antibodies
|Recombinant fragment corresponding to a region within amino acids 135 and 396 of Dhh (Uniprot ID#O43323)|
|Human (Predicted: Mouse, Rat)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (98%), Rat (98%)
|Homo sapiens desert hedgehog (DHH)|
|GDXYM; HHG-3; SRXY7|
Entrez Gene 50846 Human
Entrez Gene 13363 Mouse
Entrez Gene 84380 Rat
|This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq]|
|ES Cell Differentiation/IPSProteaseDruggable Genome Hedgehog signaling pathway|
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Sample (30 ug of whole cell lysate). A: A431 . 10% SDS PAGE. TA308606 diluted at 1:10000.