Home Antibody All anti-IL12RB1 antibodies
Also for IL12RB1 (NM_005535)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 57 and 458 of Human IL12RB1|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1|
|CD212; IL-12R-BETA1; IL12RB|
|The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]|
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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Sample(30 ug whole cell lysate) A:A431 (anti-IL12RB1 antibody diluted at 1:1000)