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Also for RASGRP4 (NM_170604)
|Synthetic peptide contain a sequence corresponding to a region within amino acids 108 and 170 of Human RASGRP4|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens RAS guanyl releasing protein 4 (RASGRP4), transcript variant a|
|guanyl nucleotide releasing protein 4; RAS guanyl releasing protein 4|
|The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
MAPK signaling pathway
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A: Jurkat (anti-RASGRP4 antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using RASGRP4 (anti-RASGRP4 antibody) antibody at 1:100 dilution.