OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-PCBP2 antibodies

Anti-PCBP2 Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308051
  • Rabbit Polyclonal antibody to PCBP2 (poly(rC) binding protein 2)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417574) , 20ug Explanation
100ul 325 In Stock
Add to Shopping Cart
WB(2)
IHC(2)
IF(1)
spacer
Also for PCBP2 (NM_005016)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 1 and 193 of PCBP2 (Uniprot ID#Q15366)
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse (Predicted: Rat, Pig, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Predicted MW Explanation 38kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Rat (100%), Pig (100%), Bovine (100%)

Reference Data

Target NameHomo sapiens poly(rC) binding protein 2 (PCBP2), transcript variant 1
Alternative NamehnRNP-E2; HNRNPE2; HNRPE2
Database LinkNP_005007
Entrez Gene 5094 Human
Entrez Gene 18521 Mouse
Entrez Gene 363005 Rat
FunctionThe protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (50 ug of whole cell lysate). A: mouse liver. 10% SDS PAGE. TA308051 diluted at 1:1000.
WB Image
Sample (30 ug of whole cell lysate). A: Raji. 10% SDS PAGE. TA308051 diluted at 1:1000.
IHC Image
PCBP2 antibody [N1C1] detects PCBP2 protein at nucleus and cytosol on mouse intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse intestine. PCBP2 antibody [N1C1] (TA308051) dilution: 1:500.
IHC Image
PCBP2 antibody [N1C1] detects PCBP2 protein at nucleus and cytosol on mouse lung by immunohistochemical analysis. Sample: Paraffin-embedded mouse lung. PCBP2 antibody [N1C1] (TA308051) dilution: 1:500.
IF Image
Immunofluorescence analysis of methanol-fixed A431, using PCBP2(TA308051) antibody at 1:200 dilution.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title