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Also for NXF1 (NM_001081491)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 449 and 598 of TAP|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Affinity purified by Protein A.
|Homo sapiens nuclear RNA export factor 1 (NXF1), transcript variant 2|
|This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq]|
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Sample (30 ug of whole cell lysate) A: A431 (anti-NXF1 antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TAP(anti-NXF1 antibody) antibody at 1:200 dilution.