Home Antibody All anti-IL12RB2 antibodies
Also for IL12RB2 (NM_001559)
|Recombinant fragment corresponding to a region within amino acids 323 and 695 of IL-12 Receptor beta2 (Uniprot ID#Q99665)|
|Human (Predicted: Dog)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Dog (80%)
|Homo sapiens interleukin 12 receptor, beta 2 (IL12RB2), transcript variant 1|
Entrez Gene 3595 Human
Entrez Gene 489550 Dog
|The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionJak-STAT signaling pathway|
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Sample(30 ug whole cell lysate). A:A431. B: Hep G2 . 7.5% SDS PAGE. TA307956 diluted at 1:5000