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Anti-NLRP3 Antibody EPR4777
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Also for NLRP3 (NM_004895)
|A recombinant protein fragment in human NALP3 was used as an immunogen.|
||FC: 1:10 - 100, IP: 1:10 - 100, WB: 1:1,000-10,000,
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1|
|AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1|
|NALP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in NALP3 are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).|
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Western blot analysis on (A) SH-SY5Y, (B) fetal brain, (C) HT-1080, and (D) Saos-2 lysates using anti-NALP3 RabMAb .
Flow cytometric analysis of permeabilized Saos-2 cells using anti-NALP3 RabMAb (red) or a rabbit IgG (negative) (green).