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Anti-NLRP3 Antibody EPR4777

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

FC(1)

OriGene Data

Immunogen	A recombinant protein fragment in human NALP3 was used as an immunogen.
Clone Name	EPR4777	Isotype	Rabbit IgG
Species Reactivity	Human	Concentration
Guaranteed Application *	WB, FC	Suggested Dilutions	FC: 1:10 - 100, IP: 1:10 - 100, WB: 1:1,000-10,000,
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1
Alternative Name	AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1
Database Link	NP_004886
Function	NALP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in NALP3 are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • NLRP3 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • NLRP3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Nlrp3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • NLRP3 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Nlrp3 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1, mGFP tagged • Lenti ORF clone of Human NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 , Myc-DDK-tagged • Myc-DDK-tagged ORF clone of Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)