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Anti-NLRP3 Antibody EPR4777
Also for NLRP3 (NM_004895)
|A recombinant protein fragment in human NALP3 was used as an immunogen.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; FC: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for ICC or IHC-P.
|Homo sapiens NLR family, pyrin domain containing 3 (NLRP3), transcript variant 1|
|AGTAVPRL; AII; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; MWS; NALP3; PYPAF1|
Entrez Gene 114548 Human
|NALP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in NALP3 are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).|
|Druggable Genome NOD-like receptor signaling pathway|
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Western blot - CIAS1 / NALP3 antibody [EPR4777]; All lanes : Anti-CIAS1 / NALP3 antibody [EPR4777] at 1/1000 dilution.Lane 1 : SH-SY5Y lysate.Lane 2 : fetal brain lysate.Lane 3 : HT-1080 lysate.Lane 4 : Saos-2 lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 118 kDa.Observed band size : 120 kDa .
Flow Cytometry - CIAS1 / NALP3 antibody [EPR4777]; Flow cytometric analysis of permeabilized Saos-2 cells, using TA307881 at a 1/10 dilution (red) or a rabbit IgG (negative) (green).