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Home Antibody All anti-TRAF3 antibodies

Anti-TRAF3 Antibody EPR1731

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307878
  • Rabbit monoclonal antibody against TRAF3(clone EPR1731)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403439) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TRAF3 was used as an immunogen.
Clone NameEPR1731 IsotypeIgG
Species ReactivityMouse, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 64 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 3 (TRAF3), transcript variant 1
Alternative NameCAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Database LinkNP_663777
Entrez Gene 7187 Human
Entrez Gene 22031 Mouse
FunctionHuman TRAF3 is an adaptor protein and signaling transducer that interacts with the cytoplasmic tails of CD40 and other TNF-receptor family members (1). The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signaling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signaling pathways and are themselves often regulated at the transcriptional and posttranslational level (2). Residues shown by mutagenesis and deletion analysis to be critical for TRAF3 binding are involved either in direct contact with TRAF3 or in intramolecular interactions that stabilize the hairpin (3). It is regulated by TANK/ITRAF, which competes with TNFRSF5/CD40 for binding (4).
Related PathwayDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayPathways in cancerSmall cell lung cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TRAF3 antibody [EPR1731]; All lanes : Anti-TRAF3 antibody [EPR1731] at 1/1000 dilution.Lane 1 : MOLT4 cell lysate.Lane 2 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 64 kDa.

 

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