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Anti-PRKCQ Antibody EPR1487(2)
Also for PRKCQ (NM_006257)
|A synthetic peptide corresponding to residues in human PKC theta was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens protein kinase C, theta (PRKCQ), transcript variant 1|
|Members of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types. PKC theta is a member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells (1). PKC theta is a Ca(2+)-independent PKC isoform that is selectively expressed in T lymphocytes (and muscle), and it is thought to play an important role in T cell receptor-induced activation (2). Among several PKC isoenzymes expressed in T cells, PKC theta is unique in being rapidly recruited to the site of TCR clustering. It has been shown that PKC theta is essential for TCR-mediated T-cell activation, but it is dispensable during TCR-dependent thymocyte development (3).|
Wnt Signaling Pathway
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Western blot - PKC theta antibody [EPR1487(2)]; All lanes : Anti-PKC theta antibody [EPR1487(2)] at 1/1000 dilution.Lane 1 : Human platelet lysate.Lane 2 : Jurkat lysate.Lysates/proteins at 10 µg/ml per lane.Predicted band size : 82 kDa.