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Home Antibody All anti-PRKCQ antibodies

Anti-PRKCQ Antibody EPR1487(2)


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA307876 Rabbit monoclonal antibody against PKC theta(clone EPR1487(2)) 100ul $325 In Stock
LC416765 PRKCQ HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human PKC theta was used as an immunogen.
Clone NameEPR1487(2) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 82 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein kinase C, theta (PRKCQ), transcript variant 1
Alternative NamenPKC-theta; PRKCT
Database LinkNP_006248
Entrez Gene 5588 Human
Entrez Gene 18761 Mouse
Entrez Gene 85420 Rat
FunctionMembers of the protein kinase C (PKC) family of serine/threonine kinases play a key role in regulating the differentiation and growth of diverse cell types. PKC theta is a member of the PKC family, and its predominant expression in hematopoietic cells suggests that it may play a role in signal transduction and growth regulatory pathways unique to these cells (1). PKC theta is a Ca(2+)-independent PKC isoform that is selectively expressed in T lymphocytes (and muscle), and it is thought to play an important role in T cell receptor-induced activation (2). Among several PKC isoenzymes expressed in T cells, PKC theta is unique in being rapidly recruited to the site of TCR clustering. It has been shown that PKC theta is essential for TCR-mediated T-cell activation, but it is dispensable during TCR-dependent thymocyte development (3).
Related PathwayProtein KinaseTranscription FactorsDruggable Genome Vascular smooth muscle contractionTight junctionT cell receptor signaling pathwayAdipocytokine signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PKC theta antibody [EPR1487(2)]; All lanes : Anti-PKC theta antibody [EPR1487(2)] at 1/1000 dilution.Lane 1 : Human platelet lysate.Lane 2 : Jurkat lysate.Lysates/proteins at 10 ug/ml per lane.Predicted band size : 82 kDa.


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