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Anti-TNFRSF12A Antibody EPR3179
Also for TNFRSF12A (NM_016639)
|A synthetic peptide corresponding to residues in human TWEAK Receptor / Fn14 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or ICC.
|Homo sapiens tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A)|
|CD266; FN14; TWEAKR|
|TWEAK Receptor / Fn14 is a single-pass type I membrane protein that is a receptor for TNFSF12/TWEAK. It is a weak inducer of apoptosis in some cell types, promotes angiogenesis, and induces the proliferation of endothelial cells (1). It induces the expression of several proinflammatory cytokines, chemokines, cell adhesion molecules, and matrix-degrading enzymes mainly through the activation of nuclear factor-kappa B (NF-κB), a major proinflammatory transcription factor (2). In addition, TWEAK Receptor / Fn14 may modulate cellular adhesion to matrix proteins. TWEAK Receptor / Fn14 is highly expressed in the heart, placenta and kidney (1).|
Cytokine-cytokine receptor interaction
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Western blot - TWEAKR antibody [EPR3179]; All lanes : Anti-TWEAKR antibody [EPR3179] at 1/1000 dilution.Lane 1 : HT-29 cell lysate.Lane 2 : HUVEC cell lysate.Lane 3 : HT-1080 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 14 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TWEAKR antibody [EPR3179]; TA307846, at 1/50 dilution, staining TWEAKR in Human uterus tissue by Immunohistochemistry.