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Home Antibody All anti-TNFRSF12A antibodies

Anti-TNFRSF12A Antibody EPR3179

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307846
  • Rabbit monoclonal antibody against TWEAK Receptor / Fn14(clone EPR3179)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402582) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for TNFRSF12A (NM_016639)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human TWEAK Receptor / Fn14 was used as an immunogen.
Clone NameEPR3179 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100
Predicted MW Explanation 14 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A)
Alternative NameCD266; FN14; TWEAKR
Database LinkNP_057723
Entrez Gene 51330 Human
Entrez Gene 27279 Mouse
Entrez Gene 302965 Rat
FunctionTWEAK Receptor / Fn14 is a single-pass type I membrane protein that is a receptor for TNFSF12/TWEAK. It is a weak inducer of apoptosis in some cell types, promotes angiogenesis, and induces the proliferation of endothelial cells (1). It induces the expression of several proinflammatory cytokines, chemokines, cell adhesion molecules, and matrix-degrading enzymes mainly through the activation of nuclear factor-kappa B (NF-κB), a major proinflammatory transcription factor (2). In addition, TWEAK Receptor / Fn14 may modulate cellular adhesion to matrix proteins. TWEAK Receptor / Fn14 is highly expressed in the heart, placenta and kidney (1).
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TWEAKR antibody [EPR3179]; All lanes : Anti-TWEAKR antibody [EPR3179] at 1/1000 dilution.Lane 1 : HT-29 cell lysate.Lane 2 : HUVEC cell lysate.Lane 3 : HT-1080 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 14 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TWEAKR antibody [EPR3179]; TA307846, at 1/50 dilution, staining TWEAKR in Human uterus tissue by Immunohistochemistry.

 

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