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Anti-PRKAA2 PHOSPHO Antibody EPR3052
Also for PRKAA2 (NM_006252)
|A phospho specific peptide corresponding to residues surrounding Serine 491 of human AMPK alpha 2 was used as an immunogen. This antibody only detects AMPK alpha 2 phosphorylated at Serine 491.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens protein kinase, AMP-activated, alpha 2 catalytic subunit (PRKAA2)|
|AMPK; AMPK2; AMPKa2; PRKAA|
|AMPK alpha 2 is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.|
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Western blot - AMPK alpha 2 (phospho S491) antibody [EPR3052]; All lanes : Anti-AMPK alpha 2 (phospho S491) antibody [EPR3052] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : 293T cell lysate treated with Lambda Phosphatase (LP).Lysates/proteins at 10 µg per lane.Predicted band size : 62 kDa.Observed band size : 62 kDa.