Invalid object name 'antibody_LocusMapping'. Anti-RAPGEF3 Antibody, EPR1672 - OriGene
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Anti-RAPGEF3 Antibody EPR1672

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307796
  • Rabbit monoclonal antibody against Epac1(clone EPR1672)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401841) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for RAPGEF3 (NM_006105)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminus of human Epac1 was used as an immunogen.
Clone NameEPR1672 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:50 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3), transcript variant 2
Alternative Namebcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Database LinkNP_006096
FunctionEpac1 is a guanine nucleotide exchange factor (GEF) for the small G protein Rap and is directly activated by cyclic AMP (cAMP). Upon cAMP binding, Epac1 undergoes a conformational change that allows the interaction of its GEF domain with Rap, resulting in Rap activation and subsequent downstream effects, including integrin-mediated cell adhesion and cell-cell junction formation (1). In addition, activation of Epac1 has been shown to promote cell adhesion and polarization and enhance chemokine-induced migration (2).
Related Pathway
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Epac1 antibody [EPR1672]; All lanes : Anti-Epac1 antibody [EPR1672] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Human heart lysate.Lane 4 : HUVEC cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 104 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Epac1 antibody [EPR1672]; Immunohistochemical analysis of Epac1 in paraffin-embedded Human kidney tissue using TA307796 at 1/50 dilution.

 

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