Transferrin receptor protein 1 (TfR1, CD71) is a plasma membrane transport glycoprotein composed of disulfide-linked polypeptide chains. It belongs to the peptidase m28 family. CD71 shows the highest level of expression in lymphocytes, placenta and neoplastic cells. CD71 is primarily involved in iron homeostasis by regulating cellular iron uptake during interaction with the HFE protein. It is also crucial in iron transportation from mother to fetus (1).
Hematopoietic cell lineage
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