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Home Antibody All anti-ACADM antibodies

Anti-ACADM Antibody EPR3708

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307768
  • Rabbit monoclonal antibody against ACADM(clone EPR3708)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400001) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for ACADM (NM_000016)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human ACADM was used as an immunogen.
Clone NameEPR3708 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:10,000-50,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens acyl-CoA dehydrogenase, C-4 to C-12 straight chain (ACADM), transcript variant 1
Alternative NameACAD1; MCAD; MCADH
Database LinkNP_000007
Entrez Gene 34 Human
Entrez Gene 11364 Mouse
Entrez Gene 24158 Rat
FunctionMedium-chain specific acyl-CoA dehydrogenase (ACADM) is a homotetramer enzyme of the mitochondrial flavoenzyme family that catalyzes the initial reaction in medium chain fatty acid beta-oxidation (1, 2). ACADM is specific for acyl chain lengths of 4 to 16 (3). It utilizes the electron transfer flavoprotein (ETF) as an electron acceptor that transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (3). Defects in the ACADM gene cause medium-chain acyl-CoA dehydrogenase deficiency (MCADD), a metabolic disorder characterized by fasting hypoglycemia (3). Mutation analysis can diagnose MCADD, which is currently screened in newborns, since its monogene may be modified by genetic variations (4).
Related PathwayDruggable Genome Fatty acid metabolismValine, leucine and isoleucine degradationbeta-Alanine metabolismPropanoate metabolismMetabolic pathwaysPPAR signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ACADM antibody [EPR3708]; All lanes : Anti-ACADM antibody [EPR3708] at 1/10000 dilution.Lane 1 : Human heart lysate.Lane 2 : fetal liver lysate.Lane 3 : HeLa cell lysate.Lane 4 : HepG2 cell lysate.Lane 5 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated Goat anti-Rabbit Ig at 1/2000 dilution.Predicted band size : 47 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ACADM antibody [EPR3708]; TA307768, at 1/100 dilution, staining ACADM in formalin-fixed, paraffin-embedded Human liver tissue by immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - ACADM antibody [EPR3708]; Immunofluorescent staining of ACADM in HeLa cells using TA307768 at 1/100 dilution.

 

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