Angiotensinogen is a precursor of angiotensin-1 and a member of the serpin family, expressed by the liver and secreted in plasma. Angiotensinogen contains angiotensin-1, 2, and 3. In response to lowered blood pressure, remin cleaves angiotensinogen and produce angiotensin-1 (1). Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while angiotensin-3 stimulates aldosterone release (2). In humans, angiotensinogen is 118 amino acids long, but its size varies between species. Defects in angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension (3).
Signaling by GPCR
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