Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT)
Synonyms:
ANHU; SERPINA8
Immunogen
A synthetic peptide corresponding to residues in human Angiotensinogen was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Angiotensinogen is a precursor of angiotensin-1 and a member of the serpin family, expressed by the liver and secreted in plasma. Angiotensinogen contains angiotensin-1, 2, and 3. In response to lowered blood pressure, remin cleaves angiotensinogen and produce angiotensin-1 (1). Angiotensin-converting enzyme (ACE) further removes a dipeptide to produce the physiologically active peptide angiotensin-2. Angiotensin-2 is involved in regulating mineral balance and volume of body fluids, while angiotensin-3 stimulates aldosterone release (2). In humans, angiotensinogen is 118 amino acids long, but its size varies between species. Defects in angiotensinogen have been linked to renal tubular dygenesis (RTD) and susceptibility to essential hypertension (3).
Related Pathway
Adipogenesis
Signaling by GPCR
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Western blot analysis on (A) fetal artery, (B) fetal heart, (C) fetal liver, (D) HepG2, (E) 293T, and (F) human plasma lysates using anti-Angiotensinogen RabMAb .
