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Home Antibody All anti-JAK3 antibodies

Anti-JAK3 Antibody EPR908(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307741
  • Rabbit monoclonal antibody against JAK3(clone EPR908(2))
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424859) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for JAK3 (NM_000215)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen.
Clone NameEPR908(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsICC: 1:250 - 500, WB: 1:1,000-10,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens Janus kinase 3 (JAK3)
Alternative NameJAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK
Database LinkNP_000206
Entrez Gene 3718 Human
FunctionJAK3 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors; upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5).
Related PathwayProtein KinaseDruggable Genome Chemokine signaling pathwayJak-STAT signaling pathwayPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - JAK3 antibody [EPR908(2)]; All lanes : Anti-JAK3 antibody [EPR908(2)] at 1/1000 dilution.Lane 1 : IM-9 cell lysate.Lane 2 : TF-1 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 125 kDa.

 

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