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Anti-JAK3 Antibody EPR908(2)
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Also for JAK3 (NM_000215)
|A synthetic peptide corresponding to residues on the N-terminus in human JAK3 was used as an immunogen.|
||ICC: 1:250 - 500, WB: 1:1,000-10,000,
|Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens Janus kinase 3 (JAK3)|
|JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK|
|JAK3 is a member of the Janus family (JAK) tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. The JAK family is constitutively associated with cytokine receptors; upon binding to the receptor, the cytokine becomes phosphorylated (1). JAK also phosphorylates the cytokine receptor on tyrosine (Tyr) residues that serve as docking sites for cytoplasmic signal transducers and activators of transcription (STAT) proteins (2). Activated STATs translocate to the nucleus to mediate gene transcription (1). JAK3 is unique among JAK family members because it serves a function in normal lymphocyte development. In addition, JAK3 is the only one that interacts with the common gamma chain of the following Interleukin receptors: IL-2, IL-4, IL-7, IL-9, and IL-15 receptors (3). Loss of JAK3 function causes a severe block in T-cell and natural killer (NK) cell development (4). Defects in JAK3 are a cause of severe combined immunodeficiency (SCID), characterized by an absence of T-cell-mediated cellular immunity (5).|
Jak-STAT signaling pathway
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Western blot analysis on (A) IM-9 and (B) TF-1 cell lysates using anti-JAK3 RabMAb .