Home Antibody All anti-MYL3 antibodies
Anti-MYL3 Antibody EPR4161
Also for MYL3 (NM_000258)
|A synthetic peptide corresponding to residues in human Myosin Light Chain 3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens myosin, light chain 3, alkali; ventricular, skeletal, slow (MYL3)|
|CMH8; MLC1SB; MLC1V; VLC1|
Entrez Gene 4634 Human
Entrez Gene 17897 Mouse
Entrez Gene 24585 Rat
|Myosin is a hexamer of 2 heavy chains and 4 light chains (1). The two pairs of light chains of muscle myosins are called essential light chains (ELC) and regulatory light chains (RLC). The light chains stabilize the long alpha helical neck of the myosin head (2). Myosin Light Chain 3 is an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform (3). In addition, it is a regulatory light chain of myosin that is involved in cardiac muscle contraction (1). However, it does not bind to calcium (1). Mutations in Myosin Light Chain 3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy (3).|
|Druggable Genome Cardiac muscle contractionHypertrophic cardiomyopathy (HCM)Dilated cardiomyopathy|
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Western blot - Myosin light chain 3 antibody [EPR4161]; All lanes : Anti-Myosin light chain 3 antibody [EPR4161] at 1/1000 dilution.Lane 1 : Human skeletal muscle lysate.Lane 2 : Human heart lysate.Lane 3 : Mouse heart lysate.Lane 4 : Mouse liver lysate.Lane 5 : Rat heart lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 22 kDa.