Homo sapiens myosin, light chain 2, regulatory, cardiac, slow (MYL2)
Synonyms:
CMH10; MLC2
Immunogen
A synthetic peptide corresponding to residues in human Myosin Light Chain 2 was used as an immunogen.
Buffer
Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Myosin, a hexamer of 2 identical heavy chains and 2 pairs of light chains, produces contractile force by moving along actin filaments and hydrolyzing ATP (1). The two pairs of light chains of muscle myosins are called essential light chains (ELC) and regulatory light chains (RLC). They stabilize the long alpha helical neck of the myosin head (2). Myosin light chain 2 (MYL2), also known as myosin II regulatory light chain, is a motor protein involved in the regulation of myosin ATPase activity in muscle cells (3). Calcium triggers the phosphorylation of MYL2 that in turn triggers myocardial contraction. Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10), a hereditary heart disorder characterized by ventricular hypertrophy (4).
Related Pathway
Focal Adhesion
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
