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Home Antibody All anti-HNF4A antibodies

Anti-HNF4A Antibody EPR3649

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307703
  • Rabbit monoclonal antibody against HNF4 Alpha (clone EPR3649 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400161) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for HNF4A (NM_000457)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the internal region of human HPA4 Alpha was used as an immunogen.
Clone NameEPR3649 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:5000; ICC: 1:100 - 1:250
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 2
Alternative NameHNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
Database LinkNP_000448
Entrez Gene 3172 Human
FunctionHNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein belonging to the steroid hormone receptor superfamily. HNF4 is commonly expressed in the liver and plays a critical role in liver development by establishing and maintaining hepatocyte differentiation (1). In human, two isoforms of HNF4 exists, alpha and gamma. HNF4 alpha is transcriptionally controlled transcription factor, which binds to DNA sites required for the transcription of alpha 1- antitrypsin, Apo CIII, transthyretin genes, and HNF1 alpha (2). HNF4 alpha interacts with PGC-1 to HNF4 alpha interacts with PGC-1 to activate gluconeogenesis, leading to lipoprotein metabolism regulation (3). HNF4 alpha defects are known cause maturity-onset diabetes of the young, type 1 (mody1) (4).
Related Pathway
TGF Beta Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-HNF4 antibody [EPR3649]; All lanes : Anti-HNF4 antibody [EPR3649] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : Human fetal liver lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 52 kDa .

 

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