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Anti-HNF4A Antibody EPR3649
Also for HNF4A (NM_000457)
|A synthetic peptide corresponding to residues near the internal region of human HPA4 Alpha was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:5000; ICC: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens hepatocyte nuclear factor 4, alpha (HNF4A), transcript variant 2|
|HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14|
|HNF4 (Hepatocyte Nuclear Factor 4) is a nuclear receptor protein belonging to the steroid hormone receptor superfamily. HNF4 is commonly expressed in the liver and plays a critical role in liver development by establishing and maintaining hepatocyte differentiation (1). In human, two isoforms of HNF4 exists, alpha and gamma. HNF4 alpha is transcriptionally controlled transcription factor, which binds to DNA sites required for the transcription of alpha 1- antitrypsin, Apo CIII, transthyretin genes, and HNF1 alpha (2). HNF4 alpha interacts with PGC-1 to HNF4 alpha interacts with PGC-1 to activate gluconeogenesis, leading to lipoprotein metabolism regulation (3). HNF4 alpha defects are known cause maturity-onset diabetes of the young, type 1 (mody1) (4). |
TGF Beta Signaling Pathway
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Western blot - Anti-HNF4 antibody [EPR3649]; All lanes : Anti-HNF4 antibody [EPR3649] at 1/1000 dilution.Lane 1 : HepG2 cell lysate.Lane 2 : Human fetal liver lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat Anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 52 kDa .