Interleukin-2 (IL-2) is an immunoregulatory cytokine that functions as a growth factor and central regulator in the immune system (1, 2). It participates in modulating the immune response by helping control the rate of clonal expansion of lymphocytes (3). IL-2 acts through a quaternary receptor signaling complex containing alpha, beta, and common gamma chain receptors (1). IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial for regulation of the immune response. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (4).
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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