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Anti-GRIN2B PHOSPHO Antibody EP1858Y
Also for GRIN2B (NM_000834)
|A phospho specific peptide corresponding to residues surrounding serine 1303 of human NMDAR2B was used as an immunogen. This antibody detects NMDAR2B phosphorylated at serine 1303.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:5000; ICC: 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B)|
|EIEE27; GluN2B; hNR3; MRD6; NMDAR2B; NR2B|
Entrez Gene 2904 Human
Entrez Gene 14812 Mouse
Entrez Gene 24410 Rat
|The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. NMDA R1 and combination of one or more NMDAR2 subunits forms NMDA receptor glutamate-gated ion channels. In this hetromer complex, NMDA R1 binds to co-agonist glycine and NMDA R2 binds to neurotransmitter glutamate (1). Several studies have suggested that protein phosphorylation of NMDA receptors may affect channel function, and additionally regulate these receptors’ synaptic trafficking and surface expression. Once activated thru phospholyation, these channels allow movement of Ca2+ and Na+ into the cell and K+ out of the cell. Serine 1303 on NMDAR2B has been identified as a major phospholyation site for CaM kinase II and PKC, regulating kinase-mediated NMNDAR2B/R1 current (2,3). NMDAR has been linked to various neurodegenerative disorders such as schizophrenia, epilepsy, and Alzheimer's disease (4). |
|TransmembraneIon Channels: Glutamate ReceptorsDruggable Genome Neuroactive ligand-receptor interactionLong-term potentiationAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)Huntington's diseaseSystemic lupus erythematosusMore Pathways >> |
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Western blot - NMDAR2B (phospho S1303) antibody [EPR1858Y]; All lanes : Anti-NMDAR2B (phospho S1303) antibody [EP1858Y] at 1/5000 dilution.Lane 1 : mouse brain lysates (untreated).Lane 2 : mouse brain lysates (treated with AP).Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP labelled IgG at 1/2000 dilution.Predicted band size : 166 kDa.Observed band size : 180 kDa .