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Home Antibody All anti-NRG3 antibodies

Anti-NRG3 Antibody EPR4148

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307640
  • Rabbit monoclonal antibody against Neuregulin 3(clone EPR4148)
100ul 325 3-7 Days
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WB(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the cytoplasmic domain of human Neuregulin 3 was used as an immunogen.
Clone NameEPR4148 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens neuregulin 3 (NRG3), transcript variant 1
Alternative NameHRG3; pro-NRG3
Database LinkNP_001010848
FunctionNeuregulin 3, or FBNRG3, is a member of the neuregulin family. This family consists of ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. Neuregulin 3 has been shown to activate tyrosine phosphorylation of its cognate receptor, ERBB4, and it is thought to influence neuroblast proliferation, migration and differentiation by signaling through ERBB4. Neuregulin 3 also promotes mammary differentiation during embryogenesis. Studies have implicated this protein in schizophrenia and schizoaffective disorder (1).
Related Pathway

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WB Image
Western blot - NRG3 antibody [EPR4148]; All lanes : Anti-NRG3 antibody [EPR4148] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : SH-SY5Y lysate.Lane 3 : C6 lysate.Lane 4 : Mouse brain lysate.Lane 5 : Rat brain lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 77 kDa.Observed band size : 56 kDa .
FC Image
Flow Cytometry - NRG3 antibody [EPR4148]; Flow cytometric analysis of permeabilized C6 cells using TA307640 (red) or a rabbit IgG (negative) (green).

 

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