S100A13 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A13 is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, it co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction (1).
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