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Home Antibody All anti-ERBB4 antibodies

Anti-ERBB4 PHOSPHO Antibody EPR2269


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SKU Description Amount Price Availability*  
TA307615 Rabbit monoclonal antibody against Her4 Phospho (pY1056)(clone EPR2269) (Phospho-Specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA phospho-specific peptide corresponding to residues surrounding Tyrosine 1056 in human HER4/ErbB4 was used as an immunogen.
Clone NameEPR2269 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000,
Predicted MW Explanation 147 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens erb-b2 receptor tyrosine kinase 4 (ERBB4), transcript variant JM-a/CVT-1
Alternative NameALS19; HER4; p180erbB4
Database LinkNP_005226
Entrez Gene 2066 Human
FunctionHER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. ErbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). ErbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Related PathwayProtein KinaseTransmembraneDruggable Genome ErbB signaling pathwayCalcium signaling pathwayEndocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ErbB 4 (phospho Y1056) antibody [EPR2269]; All lanes : Anti-ErbB 4 (phospho Y1056) antibody [EPR2269] at 1/1000 dilution.Lane 1 : A431 cell lysate (Untreated).Lane 2 : A431 cell lysate (Treated with Pervanadate).Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 147 kDa.


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