Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens regulator of G-protein signaling 9 (RGS9), transcript variant 2
Synonyms:
PERRS; RGS9L
Immunogen
A synthetic peptide corresponding to residues in human RGS9 was used as an immunogen
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Regulator of G-protein signaling 9 (RGS9) is a GTPase-activating protein. It enhances the time resolution of G protein signaling cascades by accelerating GTP hydrolysis of G alpha subunits of heterotrimeric G proteins (1, 2). RGS9 deactivates the G proteins (transducins) in the rod and cone phototransduction cascades. It is anchored to photoreceptor membranes by the transmembrane protein R9AP (RGS9 anchor protein), which enhances RGS9 activity up to 70-fold (3). As a peripheral membrane protein, RGS9 is highly expressed in the caudate and putamen and lower levels are found in the hypothalamus, nucleus accumbens and cerebellum. Defects in RGS9 are suggested as the cause of prolonged electroretinal response suppression, also known as bradyopsia (4).
Related Pathway
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