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Anti-FDPS Antibody EPR4628
Also for FDPS (NM_001135821)
|A synthetic peptide corresponding to residues near the C-terminus of human FDPS was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for ICC or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for ICC or IP.
|Homo sapiens farnesyl diphosphate synthase (FDPS), transcript variant 2|
Entrez Gene 2224 Human
|FDPS is an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption (1).|
|Druggable Genome Terpenoid backbone biosynthesisMetabolic pathways|
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Western blot - FDPS antibody [EPR4628]; All lanes : Anti-FDPS antibody [EPR4628] at 1/1000 dilution.Lane 1 : THP1 cell lysates.Lane 2 : HepG2 cell lysates.Lane 3 : Human fetal liver lysates.Predicted band size : 48 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - FDPS antibody [EPR4628]; TA307581 at 1/100 dilution staining FDPS in Human kidney by Immunohistochemistry, Paraffin-embedded tissue.