Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens casein kinase 2, beta polypeptide (CSNK2B)
Synonyms:
CK2B; CK2N; CSK2B; G5A
Immunogen
A synthetic peptide corresponding to residues near the C-terminal of human CKII beta protein was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Casein Kinase II (CKII, CK2, phosvitin kinase, troponin T kinase, casein kinase G) is a ubiquitous serine/threonine protein kinase that is highly conserved and commonly found in eukaryotic cells (found in the cytoplasm and the nucleus). CKII is a heterotetramer that consists of two catalytic subunits (alpha, alpha-prime) and two regulatory beta subunits (1). CKII can utilize both GTP and ATP as the phosphate donor and phosphorylates threonine and serine residues. Therefore, CKII is a multifunctional protein kinase with broad range of substrates (e.g. c-Myc, c-Myb, c-Fos, c-Jun, p53, Rb, HPVE7) and it has been implicated in various cell functions/processes from cell transformation to mitosis. (2)
Related Pathway
Adherens junction
Wnt Signaling Pathway
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