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Anti-ESR2 Antibody EPR3777
Also for ESR2 (NM_001437)
|A synthetic peptide corresponding to N-terminus of human ER beta was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||ICC: 1:100 - 250, IP: 1:10 - 100, WB: 1:1000 - 10,000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant a|
|ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; NR3A2|
|Estrogen Receptor beta (ER beta) is a nuclear hormone receptor which is highly homologous to ER alpha. It functions as a ligand-activated transcription factor, binding to estrogens and activation expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (1). Studies have shown ER beta play a role in modulation of the effects of ER alpha, possibly by inhibiting the transcription activation of ER alpha (2). ER beta is expressed in many tissues, including human thymus, spleen, ovary and testis. It is also highly expressed in endothelial and vascular smooth muscles cells, and the expression of ER beta in these areas has a positive correlation with increased coronary artery plaque (3).|
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Western blot - Estrogen Receptor beta antibody [EPR3777]; All lanes : Anti-Estrogen Receptor beta antibody [EPR3777] at 1/1000 dilution.Lane 1 : MCF-7 cell lysate.Lane 2 : HeLa cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 59 kDa.
Immunocytochemistry/ Immunofluorescence - Estrogen Receptor beta antibody [EPR3777]; ab92306 at 1/100 dilution staining Estrogen Receptor beta in HeLa cells by immunofluorescence.