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Home Antibody All anti-XRCC6 antibodies

Anti-XRCC6 Antibody EPR4026

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307539
  • Rabbit monoclonal antibody against Ku70(clone EPR4026)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400567) , 20ug
100ul $325 In Stock
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WB(1)
IHC(1)
IF(1)
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Also for XRCC6 (NM_001469)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen A synthetic peptide corresponding to residues in human Ku70 was used as an immunogen.
Clone NameEPR4026 IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6), transcript variant 1
Alternative NameCTC75; CTCBF; G22P1; KU70; ML8; TLAA
Database LinkNP_001460
FunctionATP-dependent DNA helicase 2 subunit 1 (Ku70) is a single stranded DNA-dependent helicase originally recognized by the sera of patients with autoimmune diseases (1, 2). It plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination (3). Ku70 forms a heterodimer with Ku80 and contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining (NHEJ) pathway (4). The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex, DNA-PK (1). Together, the Ku70/Ku80 heterodimer and DNA-PKcs are required for V(D)J recombination and DNA double-strand break repair and may also play a role in transcription regulation (5). In addition, the dimer associates with NARG1 to bind to the osteocalcin promoter and activate osteocalcin expression (1).
Related Pathway

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WB Image
Western blot - Ku70 antibody [EPR4026]; All lanes : Anti-Ku70 antibody [EPR4026] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Raji cell lysate.Lane 4 : A673 cell lysate.Lane 5 : A549 cell lysate.Lane 6 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 70 kDa.Observed band size : 70 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Ku70 antibody [EPR4026]; TA307539, at 1/100 dilution, staining Ku70 in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - Ku70 antibody [EPR4026]; TA307539, at 1/100 dilution, staining Ku70 in HeLa cells by Immunofluorescence.

 

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