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Anti-XRCC6 Antibody EPR4027
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for XRCC6 (NM_001469)
|A synthetic peptide corresponding to residues in human Ku70 was used as an immunogen.|
||FC: 1:10 - 100, ICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:1,000-10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6)|
|CTC75; CTCBF; G22P1; KU70; ML8; TLAA|
|ATP-dependent DNA helicase 2 subunit 1 (Ku70) is a single stranded DNA-dependent helicase originally recognized by the sera of patients with autoimmune diseases (1, 2). It plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination (3). Ku70 forms a heterodimer with Ku80 and contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining (NHEJ) pathway (4). The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex, DNA-PK (1). Together, the Ku70/Ku80 heterodimer and DNA-PKcs are required for V(D)J recombination and DNA double-strand break repair and may also play a role in transcription regulation (5). In addition, the dimer associates with NARG1 to bind to the osteocalcin promoter and activate osteocalcin expression (1).|
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Western blot analysis on (A) HeLa, (B) 293T, (C) A549, and (D) A431 cell lysates using anti-Ku70 RabMAb .
Immunohistochemical staining of paraffin-embedded human tonsil tissue using anti-Ku70 RabMAb .