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Home Antibody All anti-APEX1 antibodies

Anti-APEX1 Antibody EPR4023

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307530
  • Rabbit monoclonal antibody against Ape 1(clone EPR4023)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400618) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for APEX1 (NM_001641)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Ape 1 was used as an immunogen.
Clone NameEPR4023 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 35 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
Alternative NameAPE; APE1; APEN; APEX; APX; HAP1; REF1
Database LinkNP_001632
Entrez Gene 328 Human
Entrez Gene 11792 Mouse
Entrez Gene 79116 Rat
FunctionApurinic endonuclease (Ape 1) functions as a major DNA repair enzyme that is essential for embryogenesis and cell viability (1). It is involved in the base excision repair (BER) pathway and acts as a reduction-oxidation signaling factor to maintain transcription factors in an active reduced state (2). Ape 1 plays a critical role as a transcriptional coactivator for different transcription factors (i.e. AP-1, NF-kappaB, p53) in controlling different cellular processes such as apoptosis, proliferation, and differentiation (3). Elevated levels of Ape 1 have been found in ovarian, cervical, and prostate cancers (4).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome Base excision repair

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-APE1 antibody [EPR4023]; All lanes : Anti-APE1 antibody [EPR4023] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : 293T cell lysate.Lane 4 : Raji cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 35 kDa.Observed band size : 36 kDa .

 

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