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Anti-APOA2 Antibody EPR2913

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SKU Description Amount Price Availability*  
TA307528
  • Rabbit monoclonal antibody against Apolipoprotein A-II (ApoA-II) (clone EPR2913 )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400619) , 20ug Explanation
100ul $325 3-7 Days
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WB(1)
IF(1)
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Also for APOA2 (NM_001643)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Apolipoprotein A-II (ApoA-II) was used as an immunogen.
Clone NameEPR2913 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsFC: 1:50, ICC: 1:100 - 250, WB: 1:1,000 - 5,000,
Predicted MW Explanation 11 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens apolipoprotein A-II (APOA2)
Alternative NameApo-AII; ApoA-II; apoAII
Database LinkNP_001634
Entrez Gene 336 Human
FunctionApolipoprotein A II is the second most abundant protein of the high density lipoprotein particles, accounting for 20% of protein mass of HDL. The concentration of ApoA-I and ApoA-II is inversely correlated with the frequency of heart disease in human (1). In studies with mice and humans, ApoA-II levels have been associated with increased susceptibility to atherosclerosis, increased free fatty acid levels, increased body fat, and increased insulin resistance (2). ApoA-II consists of three potential amphipathic helices of 17 residues each, which contribute to the lipid-binding properties of this apolipoprotein (3). Currently, the best characterized activity of apoA-II is its potent antagonism of the anti-atherogenic and anti-inflammatory activities of ApoA-I, probably due to its competition with the latter for lipid acyl side chains of HDL (1).
Related PathwaySecreted ProteinDruggable Genome PPAR signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Apolipoprotein A II antibody [EPR2913]; Anti-Apolipoprotein A II antibody [EPR2913] at 1/1000 dilution + Human plasma lysate at 10 ug.Secondary.HRP labelled goat anti-rabbit antibody at 1/2000 dilution.Predicted band size : 11 kDa.Observed band size : 11 kDa.
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Immunocytochemistry/ Immunofluorescence - Apolipoprotein A II antibody [EPR2913]; Ab92478 at 1/100 dilution staining Apolipoprotein A II in HepG2 cells by immunofluorescence.
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