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Anti-BDNF Antibody EPR1292
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Also for BDNF (NM_001709)
|A synthetic peptide corresponding to residues in human BDNF was used as an immunogen.|
|Human, Mouse, Rat
||IHC: 1:100 - 250, WB: 1:1,000 - 10,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens brain-derived neurotrophic factor (BDNF), transcript variant 4|
|Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptide factor initially regarded to be responsible for neuron proliferation, differentiation and survival through its uptake at nerve terminals and retrograde transport to the cell body (1). BDNF has been linked to a variety of neurological and psychological conditions such as Huntington's disease, Alzheimer's disease, depression and anxiety. Studies show that transgenic overexpression of the neurotrophin BDNF has an unexpected facilitatory effect on anxiety-like behavior, concomitant with increased spinogenesis in the basolateral amygdala (2). In addition, BDNF enhances the neurite outgrowth on immature astrocytes. A multifactorial strategy based on transplantation of neonatal astrocytes in the presence of additional BDNF may stimulate axon regrowth after experimental injury to the central nervous system (3). The precursor pro-BDNF is 27-34 kDa before proteolytic cleavage, whereas the mature form of BDNF is 14 kDa.|
MAPK signaling pathway
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Western blot analysis on (A) U87-MG, (B) C6, (C) SH-SY5Y, (D) Neuron-2a, (E) PC-12 cell lysates, and (F) BDNF recombinant protein using anti-BDNF RabMAb .
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-BDNF RabMAb .