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Home Antibody All anti-RUNX1 antibodies

Anti-RUNX1 Antibody EPR3098

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307515
  • Rabbit monoclonal antibody against RUNX1(clone EPR3098)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419764) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(6)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RUNX1 was used as an immunogen.
Clone NameEPR3098 IsotypeTissue culture supernatant
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,ICC/IF or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC/IF or IP.

Reference Data

Target NameHomo sapiens runt-related transcription factor 1 (RUNX1), transcript variant 1
Alternative NameAML1; AML1-EVI-1; AMLCR1; CBFA2; EVI-1; PEBP2aB
Database LinkNP_001745
FunctionRUNX1 (PEBP2-alpha B, Runt-related transcription factor 1, AML1) is a pivotal transcription factor essential for haematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta (1). So far, 11 isoforms of RUNX1 has been reported. It binds DNA in cooperation with CBFbeta to activate or repress transcription, dependent upon cellular context and interaction with a variety of co-activators and co-repressors (2). RUNX1 is required for maturation of megakaryocytes and differentiation of T and B cells (3). It is one of the most frequent targets of chromosome translocations associated with leukemia (4). Mutation at the C-terminal region of RUNX1 might predict acute myeloid leukemia transformation (5).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-RUNX1 / AML1 antibody [EPR3098]; All lanes : Anti-RUNX1 / AML1 [EPR3098] antibody at 1/1000 dilution.Lane 1 : Molt 4 cell lysate.Lane 2 : Human fetal thymus lysate.Lane 3 : Mouse thymus lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 48 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RUNX1 / AML1 antibody [EPR3098]; Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelling RUNX1 / AML1 with TA307515 at 1/100.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-RUNX1 / AML1 antibody [EPR3098](TA307515); Immunohistochemical analysis of paraffin embedded normal Human spleen tissue using TA307515 showing +ve staining.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-RUNX1 / AML1 antibody [EPR3098](TA307515); Immunohistochemical analysis of paraffin embedded normal Human testis tissue using TA307515 showing +ve staining.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-RUNX1 / AML1 antibody [EPR3098](TA307515); Immunohistochemical analysis of paraffin embedded normal Human heart tissue using TA307515 showing -ve staining.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-RUNX1 / AML1 antibody [EPR3098](TA307515); Immunohistochemical analysis of paraffin embedded normal Human colon tissue using TA307515 showing +ve staining.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-RUNX1 / AML1 antibody [EPR3098](TA307515); Immunohistochemical analysis of paraffin embedded normal Human breast tissue using TA307515 showing +ve staining.

 

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