Home All anti-CD79A antibodies
Anti-CD79A Antibody EP3618
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for CD79A (NM_001783)
|A synthetic peptide derived from the extracellular region of human CD79a protein.|
||FC: 1:140, IHC: 1:100 - 250, WB: 1:5000 - 20,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens CD79a molecule, immunoglobulin-associated alpha (CD79A), transcript variant 1|
|CD79a (mb-1/ B lymphocyte-specific MB-1 protein) was originally identified on the basis of its restricted expression in lymphocytes of B lineage (1). CD79a associates with surface IgM-receptors; it has been implicated in the signal transduction pathways and in the regulation of type of type 2A-related serine/threonine phosphatases catalytic activity (2). A disulphide-linked heterodimer, consisting of CD79a (mb-1) and CD79b / B29 polypeptides, non-covalently associates with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79 is required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also CD79 interacts with and increases activity of some Src-family tyrosine kinases. (3). |
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A. Western blot analysis on (A) Raji, (B) Daudi cell lysates and (C) Hu-tonsil and (D) Hu-spleen tissue lysate using anti-CD79 RabMAb .
B. Immunohistochemical analysis of paraffin-embedded human tonsils tissue using anti-CD79 RabMAb .