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Home Antibody All anti-GATA1 antibodies

Anti-GATA1 Antibody EP2819Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307490
  • Rabbit monoclonal antibody against Gata1 (clone EPR2618Y )
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400758) , 20ug
100ul 325
$292
3-7 Days
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WB(1)
FC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to N-terminus of human Gata-1 was used as an immunogen.
Clone NameEP2819Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:2000; FC: 1:50
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC/IF,IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for ICC/IF,IHC-P or IP.

Reference Data

Target NameHomo sapiens GATA binding protein 1 (globin transcription factor 1) (GATA1)
Alternative NameERYF1; GATA-1; GF-1; GF1; NF-E1; NFE1; XLANP; XLTDA; XLTT
Database LinkNP_002040
FunctionGlobin transcription factor 1 (GATA-1) is a transcription activator belonging to the GATA family of transcription factors with importance in cell growth. GATA-1 is a Cys2-Cys2 zinc finger DNA binding protein commonly found in erthroid (red blood cell) and emagkaryotic (platelet producing cell) and it is critical in the development process of both (1). It binds to the consensus sequence of [AT]GATA[AG] within regulatory regions of globin genes and genes in erythroid cells, leading to transcription of alpha spectrin structural protein necessary for red blood cell’s shape. In human, GATA-1 can enhance transcription rate up to 100 times (2). Mutation to GATA-1 encoding gene has been implicated to X-linked dyserythropoietic anemia, thrombocytopenia, Down’s syndrome in children, congenital transient myeloproliferative syndrome, and acute megakaryocytic leukemia (2, 3).
Related Pathway

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WB Image
Western blot - GATA1 antibody [EP2819Y]; Anti-GATA1 antibody [EP2819Y] at 1/2000 dilution + K562 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/1000 dilution.Predicted band size : 43 kDa.Observed band size : 43 kDa.
FC Image
Flow Cytometry - GATA1 antibody [EP2819Y]; Flow cytometric analysis of permeabilized K562 cells using TA307490 at a 1/50 dilution (red) or a rabbit IgG (negative) (green).

 

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