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Anti-HMGB1 Antibody EPR3507
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for HMGB1 (NM_002128)
|A synthetic peptide corresponding to residues in human HMGB1 was used as an immunogen.|
|Human, Mouse, Rat
||FC: 1:20, IHC: 1:250 - 500, IP: 1:20, WB: 1:10,000 - 50,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens high mobility group box 1 (HMGB1)|
|HMG1; HMG3; SBP-1|
|High-mobility group box 1 protein (HMGB1) is a nuclear DNA-binding protein, which also functions as a pleiotropic cytokine, implicated in the pathology of several different immune-mediated diseases (1). As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription. Recent studies identified extracellular HMGB1 as a potent macrophage-activating factor, signaling via the receptor for advanced glycation end-products to induce inflammatory responses. HMGB1 mediates endotoxin lethality, acute lung injury, arthritis induction, activation of macrophages, smooth muscle cell chemotaxis, and epithelial cell barrier dysfunction (2). |
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A. Western blot analysis on (A) SKBR-3, (B) HeLa and (C) HepG2 cell lysates using anti-HMGB1 RabMAb .
B. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-HMGB1 RabMAb .