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Anti-HMGB1 Antibody EPR3507

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human HMGB1 was used as an immunogen.
Clone Name	EPR3507	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	FC: 1:20, IHC: 1:250 - 500, IP: 1:20, WB: 1:10,000 - 50,000,
Buffer	Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens high mobility group box 1 (HMGB1)
Alternative Name	HMG1; HMG3; SBP-1
Database Link	NP_002119
Function	High-mobility group box 1 protein (HMGB1) is a nuclear DNA-binding protein, which also functions as a pleiotropic cytokine, implicated in the pathology of several different immune-mediated diseases (1). As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription. Recent studies identified extracellular HMGB1 as a potent macrophage-activating factor, signaling via the receptor for advanced glycation end-products to induce inflammatory responses. HMGB1 mediates endotoxin lethality, acute lung injury, arthritis induction, activation of macrophages, smooth muscle cell chemotaxis, and epithelial cell barrier dysfunction (2).
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of high-mobility group box 1 (HMGB1) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • HMGB1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • HMGB1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Hmgb1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • HMGB1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Hmgb1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens high mobility group box 1 (HMGB1) as transfection-ready DNA • Lenti ORF clone of Human high mobility group box 1 (HMGB1) , Myc-DDK-tagged • Lenti ORF clone of Human high mobility group box 1 (HMGB1), mGFP tagged • GFP-tagged ORF clone of Homo sapiens high mobility group box 1 (HMGB1) as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens high mobility group box 1 (HMGB1) as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens high mobility group box 1 (HMGB1) as transfection-ready DNA • Homo sapiens high mobility group box 1 (HMGB1) as transfection-ready DNA Functional Proteins • HMG1 (High Mobility Group 1 protein), 10,000 units • HMG1 (High Mobility Group 1 protein), 25,000 units • HMG1 (Native from Calf Thymus), 10,000 units • HMG1 (Native from Calf Thymus), 25,000 units

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)