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Anti-HNRNPK Antibody EPR944
Also for HNRNPK (NM_002140)
|A synthetic peptide corresponding to residues in human hnRNP K was used as an immunogen|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000 - 1:200000; IHC-P: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens heterogeneous nuclear ribonucleoprotein K (HNRNPK), transcript variant 1|
|CSBP; HNRPK; TUNP|
|The hnRNP K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNP K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes; although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis; for instance, hnRNP K increases transcription of the oncogene c-myc, and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).|
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Western blot - Anti-hnRNP K antibody [EPR944]; All lanes : Anti-hnRNP K antibody [EPR944] at 1/50000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : A549 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 50 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-hnRNP K antibody [EPR944]; Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue labelling hnRNP K with TA307474 at 1/100 dilution.