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Anti-KRT15 Antibody EP1613
Also for KRT15 (NM_002275)
|A synthetic peptide corresponding to residues on the N-terminus of human Cytokeratin 15 was used as an immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||FC: 1:50, WB: 1:500 - 1000,
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens keratin 15 (KRT15)|
|CK15; K15; K1CO|
|Cytokeratin 15 (CK15) is a type I keratin without a defined type II partner whose expression in epidermal diseases has not been investigated. A monoclonal antibody raised against the last 17 amino acids of the CK15 polypeptide show that CK-15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Although CK-15 in normal hair follicles was virtually absent from hair bulbs, it was expressed by a subset of keratinocytes in the outer root sheath (2). In human conjunctival epithelium, strong expression of CK-15 was observed in basal cells, whereas CK19 was expressed in both basal and suprabasal layers. Although the expression of K15 and K19 differ in humans and mice, specific staining patterns can be used to characterize the epithelial phenotype in normal and diseased ocular surface (3). |
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Western blot - Cytokeratin 15 antibody [EP1613]; Anti-Cytokeratin 15 antibody [EP1613] at 1/5000 dilution + A431 cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 49 kDa.