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Anti-NEK2 Antibody EPR3787


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against NEK2(clone EPR3787)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419288) , 20ug Explanation
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human NEK2 was used as an immunogen.
Clone NameEPR3787 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens NIMA-related kinase 2 (NEK2), transcript variant 1
Alternative NameHsPK21; NEK2A; NLK1; PPP1R111; RP67
Database LinkNP_002488
Entrez Gene 4751 Human
FunctionNEK2, a member of the NEK Serine/Threonine protein kinase family, is a protein kinase that is involved in cell cycle regulation (1). It promotes the splitting of duplicated centrosomes during the G2/M transition of mitosis through the phosphorylation of core centriolar proteins (2). Almost undetectable during G1, NEK2 accumulates progressively throughout S phase, reaching maximal levels in late G2 (1). It is structurally related to the nimA kinase (never in mitosis A), which also regulates cell cycle progression (3). During mitotic progression, NEK2 may be functionally similar to nimA in controlling the timing of mitotic entry, chromatin condensation, spindle organization, and cytokinesis (4). Nek2 is ubiquitously expressed in humans as two alternative splice variants, called Nek2A (48 kDa) and Nek2B (44 kDa). Nek2A exclusively phosphorylates and activates NEK11 in G1/S-arrested cells in the nucleolus, while the shorter isoform (Nek2B) is predominantly cytoplasmic (1, 2). Both isoforms are detected in primary blood lymphocytes as well as adult transformed cells (1).
Related PathwayProtein KinaseDruggable Genome

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WB Image
Western blot - NEK2 antibody [EPR3787]; All lanes : Anti-NEK2 antibody [EPR3787] at 1/1000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : 293T cell lysate.Lane 3 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 52 kDa.


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