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Home Antibody All anti-PLCG1 antibodies

Anti-PLCG1 PHOSPHO Antibody EP1502Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307422
  • Rabbit monoclonal antibody against Phospho PLC gamma I (pY1245) (clone EP1502Y ) (Phospho-Specific)
100ul 325 3-7 Days
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WB(1)
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Also for PLCG1 (NM_002660)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to phospholyated residue surrounding tyrosine 1245 of human PLC?I was used.
Clone NameEP1502Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2000 - 1:5000; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for IHC-P or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1
Alternative NameNCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Database LinkNP_002651
FunctionThe phospholipase C gamma-1 (PLC?I) is a member of phospholipase C family which catalyzes the hydrolysis of phospholipids to yield second messengers such as diacylglycerols (DAG) and water-soluble phosphorylated derivatives of the lipid head groups. These second messengers play a crucial role in transmembrane signaling and are involved in the regulation of several cellular functions, such as cell differentiation and proliferation (1). PLC?I interacts with variety of signaling molecules via its two SH2 domains and a single SH3 domain and it is activated by phosphorylation on Tyr783 through interaction with non-receptor and receptor tyrosine kinases. Interaction with activated receptors (e.g. PDGFR and EGFR) leads to phosphorylation on Tyr771, Tyr783, and Tyr1245 (2). Phosphorylations at Tyr783 and 1245 might be significant for adhesion PLC?I to fibronectin during integrin initiated fibronectin adhesion (3)
Related Pathway
EGFR1 Signaling Pathway
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Phospholipase C gamma 1 (phospho Y1245) antibody [EP1502Y]; All lanes : Anti-Phospholipase C gamma 1 (phospho Y1253) antibody [EP1502Y] at 1/2000 dilution.Lane 1 : Jurkat cell lysate.Lane 2 : Jurkat + Pervanadate cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP conjugated goat anti-rabbit at 1/2000 dilution.Predicted band size : 149 kDa.Observed band size : 149 kDa.

 

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