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Home All anti-PLCG1 antibodies
Anti-PLCG1 Phospho Antibody EP1502Y
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for PLCG1 (NM_002660)
OriGene Data
| A synthetic peptide corresponding to phospholyated residue surrounding tyrosine 1245 of human PLC?I was used. |
| EP1502Y |
Rabbit IgG |
| Human |
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| WB |
ICC: 1: 100 - 250, WB: 1:2,000 - 5,000, |
| Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| (Protein A or G Sepharose) |
Reference Data
| Homo sapiens phospholipase C, gamma 1 (PLCG1), transcript variant 1 |
| NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1 |
| NP_002651 |
| The phospholipase C gamma-1 (PLC?I) is a member of phospholipase C family which catalyzes the hydrolysis of phospholipids to yield second messengers such as diacylglycerols (DAG) and water-soluble phosphorylated derivatives of the lipid head groups. These second messengers play a crucial role in transmembrane signaling and are involved in the regulation of several cellular functions, such as cell differentiation and proliferation (1). PLC?I interacts with variety of signaling molecules via its two SH2 domains and a single SH3 domain and it is activated by phosphorylation on Tyr783 through interaction with non-receptor and receptor tyrosine kinases. Interaction with activated receptors (e.g. PDGFR and EGFR) leads to phosphorylation on Tyr771, Tyr783, and Tyr1245 (2). Phosphorylations at Tyr783 and 1245 might be significant for adhesion PLC?I to fibronectin during integrin initiated fibronectin adhesion (3) |
EGFR1 Signaling Pathway Hemostasis |
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
A. Western blot analysis on (1) Jurkat and (2) Jurkat + Pervanadate cell lysates using anti- PLC? I (pY1245) RabMAb (catalog #2125-1), 1:2,000 dilution.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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