Home All anti-PKN1 antibodies
Anti-PKN1 Antibody EPR3238
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Also for PKN1 (NM_002741)
|A synthetic peptide corresponding to residues near the C-terminus of human PKN1 was used as an immunogen.|
|Human, Mouse, Rat
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens protein kinase N1 (PKN1), transcript variant 2|
|DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1|
|Protein kinase N (PKN) is a fatty acid- and Rho-activated serine/threonine protein kinase involved in the regulation of cell motility by association with cytoskeletal components such as neurofilament and alpha-actinin (1). Serine/threonine-protein kinase N1 (PKN1) belongs to the protein kinase C superfamily. It is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The phosphorylation of PKN1 by PDK1 may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis (2).|
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Western blot analysis on (A) SH-SY-5Y, (B) U937, (C) Jurkat cell lysates using anti-PKN1 RabMAb .
Flow cytometric analysis of permeabilized Jurkat cells using anti- PKN1 RabMAb (red) or a rabbit IgG (negative) (green).